Recommendations on Vitamin K: Vitamin K should be given to all newborn infants as a single, intramuscular dose of 0.5 to 1 mg. Additional research should be conducted on the efficacy, safety, and bioavailability of oral vitamin K to prevent late vitamin K deficiency bleeding. At the end of the study, participants receiving either phylloquinone or MK-4 had significantly lower levels of undercarboxylated osteocalcin compared to those receiving placebo. The AIs for infants are based on the calculated mean vitamin K intake of healthy breastfed infants and the assumption that infants receive prophylactic vitamin K at birth as recommended by American and Canadian pediatric societies [3]. A dosage of 2.5 to 25 mg or more (rarely up to 50 mg) is recommended, the amount and route of administration depending upon the severity of the condition and response obtained. Clin Pharmacokinet 2005;44:1227-46. American Academy of Pediatrics Committee on Fetus and Newborn. ��d�iT�� Ĩ��DL���Wp�~���j�[email protected]��`V#!�r8��T�9Ƽі Baltimore, MD: Lippincott Williams & Wilkins; 2014:305-16. Some examples are provided below. Endocrine and nutritional management of the post-bariatric surgery patient: an Endocrine Society Clinical Practice Guideline. People taking warfarin and similar anticoagulants need to maintain a consistent intake of vitamin K from food and supplements because sudden changes in vitamin K intakes can increase or decrease the anticoagulant effect [47]. Consuming vegetables at the same time as some fat improves phylloquinone absorption from the vegetables, but the amount absorbed is still lower than that from oils. From there, vitamin K is incorporated into chylomicrons, secreted into the lymphatic capillaries, transported to the liver, and repackaged into very low-density lipoproteins [2,10]. Vitamin K and its derivatives contain a 2-methyl-1,4- naphthoquinone nucleus with a lipophilic side chain . Like dietary lipids and other fat-soluble vitamins, ingested vitamin K is incorporated into mixed micelles via the action of bile and pancreatic enzymes, and it is absorbed by enterocytes of the small intestine [10]. People with malabsorption syndromes and other gastrointestinal disorders, such as cystic fibrosis, celiac disease, ulcerative colitis, and short bowel syndrome, might not absorb vitamin K properly [3,5,25]. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. Suttie JW. Dosing guidelines for rapid reversal in preparation for invasive procedure: 1. [, Jagannath VA, Fedorowicz Z, Thaker V, Chang AB. 3 0 obj Table 1 lists the current AIs for vitamin K in micrograms (mcg). [, Binkley N, Harke J, Krueger D, Engelke J, Vallarta-Ast N, Gemar D, et al. Natural Medicines Comprehensive Database. In healthy people, fasting concentrations of phylloquinone in plasma have been reported to range from 0.29 to 2.64 nmol/L [12]. [. However, it is not clear whether this measure can be used to quantitatively assess vitamin K status. Pederson et al 5 evaluated the effect of different amounts of vitamin K 1 ingested in the diet, while Pengo et al 6 and Weibert et al 7 examined the [, Chan R, Leung J, Woo J. Haemostasis 2000;30:298-307. Newborn Infection Control & Prevention Guidelines; ... which is organized by system for easy access to the clinical team. Diet. It is also available in dietary supplements containing only vitamin K or vitamin K combined with a few other nutrients, frequently calcium, magnesium, and/or vitamin D. In addition, respiratory policies, drug administration guidelines (DAGs), or any nursing policy, procedure, and guidelines that are related to the … Elder SJ, Haytowitz DB, Howe J, Peterson JW, Booth SL. 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